Cancer cells can fight the foot soldiers back by pushing a brake on the T cells that will turn them off.
This 'brake' is a molecule on the surface of T cells called CTLA-4. Until now, most scientists agreed that CTLA-4 was only present on T cells and other cells of the same lineage.
But Baylor College of Medicine researchers have discovered that CTLA-4 is also produced and secreted by dendritic cells, which are the 'generals' of the T cells in the battle against cancer.
The results appear in Stem Cells...(continua)